CBD & Stress

Wisdom CBD_Stress-Relax_
Image by Gerd Altmann

The following statistics from the American Institute of Stress reveal stress is a highly prevalent condition in the United States.

U.S Stress Statistics from the American Institute of StressData
Percent of people who regularly experience physical symptoms
caused by stress
77 %
Regularly experience psychological symptoms caused by stress73 %
Feel they are living with extreme stress33 %
Feel their stress has increased over the past five years48 %
Cited money and work as the leading cause of their stress76 %
Reported lying awake at night due to stress48 %

What is Stress?

Wisdom CBD_CBD and Stress

Project CBD defines stress, saying, “Stress is primarily a physical response to feeling attacked, resulting in the release of hormones and chemicals like adrenaline, cortisol and norepinephrine.”

According to Medicine.net, “stress is a physical, mental, or emotional factor that causes bodily or mental tension. Stresses can be external (from the environment, psychological, or social situations) or internal (illness, or from a medical procedure). Stress can initiate the “fight or flight” response, a complex reaction of neurologic and endocrinologic system

Chronic Stress vs. Acute Stress

The American Psychological Association (APA) places stress in two main categories: 1. Acute 2. Chronic

According to the APA, “Acute stress, the most common form of stress, is short-term and stems from the demands and pressures of the recent past and anticipated demands and pressures of the near future (APA, 2011).”

On the other hand, the APA states that, “Chronic stress, a long term form of stress, derives from unending feelings of despair/hopelessness, as a result of factors such as poverty, family dysfunction, feelings of helplessness and/or traumatic early childhood experience (APA, 2011).”

Wisdom CBD_Stress and CBD

Effects of Stress

According to the Mayo Clinic, common effects of stress include

On your bodyOn your moodOn your behavior
HeadacheAnxietyOvereating or undereating
Muscle tension or
RestlessnessAngry outbursts
Chest painLack of motivation or
Drug or alcohol misuse
FatigueFeeling overwhelmedTobacco use
Change in sex driveIrritability or angerSocial withdrawal
Stomach upsetSadness or depressionExercising less often
Sleep problems

Stress Management Techniques

WebMD proposes the following stress management techniques .

  • Keep a positive attitude.
  • Accept that there are events that you cannot control.
  • Be assertive instead of aggressive. Assert your feelings, opinions, or beliefs instead of becoming angry, defensive, or passive.
  • Learn and practice relaxation techniques; try meditation, yoga, or tai-chi for stress management.
  • Exercise regularly. Your body can fight stress better when it is fit.
  • Eat healthy, well-balanced meals.
  • Learn to manage your time more effectively.
  • Set limits appropriately and learn to say no to requests that would create excessive stress in your life.
  • Make time for hobbies, interests, and relaxation.
  • Get enough rest and sleep. Your body needs time to recover from stressful events.
  • Don’t rely on alcohol, drugs, or compulsive behaviors to reduce stress.
  • Seek out social support. Spend enough time with those you enjoy.
  • Seek treatment with a psychologist or other mental health professional trained in stress management or biofeedback techniques to learn healthy ways of dealing with the stress in your life.

How does CBD affect stress?

CBD has been shown to inhibit the enzyme responsible for degrading the endocannabinoid AEA (Anandamide). Naturopath Jacqueline Jacques writes, “Because anandamide is normally rapidly broken down by FAAH (fatty acid amide hydrolase) , and because CBD regulates FAAH, CBD’s primary importance is its ability to maintain anandamide levels, thus enhancing anandamide’s beneficial effect in the ECS (Endocannabinoid System). CBD also binds weakly to CB1 and CB2 receptors and has a range of activity outside of the ECS that contribute to its health benefits.”

So CBD indirectly prevents the degradation of anandamide. “These data create a compelling argument that eCB (endo Cannabinoid) signaling is an important regulatory system in the brain that largely functions to buffer against many of the effects of stress …”(7)

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  1. Fogaça MV, Campos AC, Coelho LD, Duman RS, Guimarães FS.“The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling.” Neuropharmacology. 2018 Jun;135:22-33. doi: 10.1016/j.neuropharm.2018.03.001. Epub 2018 Mar 3.
  2. Elms L, Shannon S, Hughes S, Lewis N. Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. J Altern Complement Med. 2018 Dec 13. doi: 10.1089/acm.2018.0437. [Epub ahead of print]
  3. de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, Machado S, Arias-Carrión O, Crippa JA, Zuardi AW, Nardi AE, Silva AC . Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets. 2014;13(6):953-60.
  4. Alline C. Campos, Zaira Ortega, Javier Palazuelos, Manoela V. Fogaça, Daniele C. Aguiar, Javier Díaz-Alonso, Silvia Ortega-Gutiérrez, Henar Vázquez-Villa, Fabricio A. Moreira, Manuel Guzmán. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. International Journal of Neuropsychopharmacology, Volume 16, Issue 6, July 2013, Pages 1407–1419,
  5. R J Bluett, J C Gamble-George, D J Hermanson, N D Hartley, L J Marnett, and S Patel. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. Transl Psychiatry. 2014 Jul; 4(7): e408.Published online 2014 Jul
  6. Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M. Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice. Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1
  7. Maria Morena, Sachin Patel, Jaideep S Bains, and Matthew N Hill. . Neurobiological Interactions Between Stress and the Endocannabinoid System. Neuropsychopharmacology. 2016 Jan; 41(1): 80–102.Published online 2015 Jul 8.
  8. PTSD Treatments with Cannabinoids. http://profofpot.com/ptsd-cannabinoids/

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